Oxford is a city in, and the county seat of, Lafayette County, Mississippi, United States. Founded in 1837, it was named after the British university city of Oxford in hopes of having the state university located there, which it did successfully attract.As of the 2010 US Census, the population is 18,916; the Census Bureau estimates the city's 2013 population at 20,865. Oxford is the home of the University of Mississippi, founded in 1848, also commonly known as "Ole Miss".